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Thursday, December 10, 2015

Electron Transport System (ETS)

All NADH+H+ Produced during Glycolysis & Krebs cycle is oxidized by NADH-dehydrogenase and electrons are transported to Ubiquinone(UQ)via FMN.
In ETS, , Molecular Oxygen (O2)acts as terminal electron acceptor.
Electrons from NADH+H+ is transported through FMN, UQ (Hydrogen Carrier, Cytochromes(b,C1,C,a-a3) and finally to O2 which takes 2H+ from matrix and form H2O.
During transport of electron, proton (H+) is pumped by UQ to inter membrane space from matrix causing formation of proton gradient (due to increase in protons in inter membrane space and decrease in matrix).
Breaking of this gradient and return of these protons(H+)through ATP synthase/ Fo-F1 particle/ oxysomes located in inner membrane cause synthesis of ATP.
Since oxidation of NADH+H+ is the cause of formation of proton gradient and ATP synthesis thereupon, so this method of ATP synthesis is called as oxidative phosphorylation.
Return of 2H+ from inter membrane space to matrix through ATP synthase release sufficient energy to synthesise one ATP molecule.
On oxidation of 1 molecule of NADH+H+ pumps 6H+, therefore it produces 3 ATP molecules while oxidation of FADH2 pumps only 4H+, so it produces 2 ATP molecules.

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